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Test Code DHR Dihydrorhodamine (DHR) Flow Cytometric Test, Blood

Important Note

Contact the Referral Lab to coordinate collection and transport of samples at 413-322-4667

Useful For

Diagnosis of chronic granulomatous disease (CGD), X-linked and autosomal recessive forms, Rac2 deficiency, complete myeloperoxidase (MPO) deficiency; monitoring chimerism and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase function posthematopoietic cell transplantation


Assessing residual NADPH oxidase activity pretransplant


Identification of carrier females for X-linked CGD; assessment of changes in lyonization with age in carrier females

Reporting Name

DHR Flow, B

Specimen Type

WB Sodium Heparin

Shipping Instructions

Specimens are required to be received in the laboratory weekdays and by 4 p.m. on Friday. Draw and package specimen as close to shipping time as possible. Ship specimen overnight in an Ambient Mailer-Critical Specimens Only (T668).


It is recommended that specimens arrive within 24 hours of draw.


Samples arriving on the weekend may be canceled.

Necessary Information

Ordering physician name and phone number are required.

Specimen Required

A whole blood sodium heparin specimen and a whole blood sodium heparin control specimen from an unrelated, healthy donor are required.


Supplies: Ambient Mailer - Critical Specimens Only (T668)



Container/Tube: Green top (sodium heparin)

Specimen Volume: 5 mL

Collection Instructions: Send specimen in original tube. Do not aliquot.


Normal Control:

Container/Tube: Green top (sodium heparin)

Specimen Volume: 5 mL

Collection Instructions:

1. Draw a control specimen from a normal (healthy), unrelated person within an hour of the patient.

2. Label clearly on outermost label normal control.

3. Send specimen in original tube. Do not aliquot.

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
WB Sodium Heparin Ambient 48 hours

Reject Due To


Mild OK; Gross reject


Mild OK; Gross reject




Lithium heparin
Green top microtube

Reference Values

Result Name


Cutoff for Defining Normal

% PMA ox-DHR+






% fMLP ox-DHR+






Control % PMA ox-DHR+



Control MFI PMA ox-DHR+



Control % fMLP ox-DHR+



Control MFI fMLP ox-DHR+




The appropriate age-related reference values for Absolute Neutrophil Count will be provided on the report.

Day(s) and Time(s) Performed

Monday through Friday

Specimen must be received by 4 p.m. on Friday.

Performing Laboratory

Mayo Medical Laboratories in Rochester

CPT Code Information



LOINC Code Information

Test ID Test Order Name Order LOINC Value
DHR DHR Flow, B In Process


Result ID Test Result Name Result LOINC Value
ANC Absolute Neutrophil Count 751-8
PMAP % PMA ox-DHR+ 85376-2
PMAM MFI PMA ox-DHR+ 85374-7
FMPPP % FMLP ox-DHR+ 85373-9
FMPM MFI fMLP ox-DHR+ 85370-5
ANCC Control Absolute Neutrophil Count 85369-7
PMAPC Control % PMA ox-DHR+ 85377-0
PMAMC Control MFI PMA ox-DHR+ 85375-4
FMPPC Control % fMLP ox-DHR+ 85372-1
FMPMC Control MFI fMLP ox-DHR+ 85371-3
DHRI Interpretation 69052-9

Method Name

Flow Cytometry

Test Classification

This test was developed using an analyte specific reagent. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.