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Test Code DOC 11-Deoxycorticosterone, Serum

Secondary ID


Useful For

Diagnosis of suspected 11-hydroxylase deficiency, including the differential diagnosis of 11 beta-hydroxylase 1 (CYP11B1) versus 11 beta-hydroxylase 2 (CYP11B2) deficiency, and in the diagnosis of glucocorticoid-responsive hyperaldosteronism


Evaluating congenital adrenal hyperplasia newborn screen-positive children, when elevations of 17-hydroxyprogesterone are only moderate, suggesting possible 11-hydroxylase deficiency

Testing Algorithm

See Steroid Pathways in Special Instructions.

Special Instructions

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

11-Deoxycorticosterone, S

Specimen Type


Specimen Required


Preferred: Red top

Acceptable: Serum gel

Specimen Volume: 0.5 mL

Collection Instructions: Morning (8 a.m.) specimen is preferred.

Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 21 days
  Frozen  21 days
  Ambient  7 days

Reject Due To


Mild OK; Gross reject


Mild OK; Gross OK


Mild OK; Gross OK



Reference Values

≤18 years: <30 ng/dL

>18 years: <10 ng/dL

Day(s) and Time(s) Performed

Tuesday; 10 a.m.

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
DOCS 11-Deoxycorticosterone, S In Process


Result ID Test Result Name Result LOINC Value
46922 11-Deoxycorticosterone, S 1656-8