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Test Code NSE Neuron-Specific Enolase (NSE), Serum

Reporting Name

Neuron Specific Enolase, S

Useful For

A follow-up marker in patients with neuron-specific enolase-secreting tumors of any type


An auxiliary test in the diagnosis of small cell lung carcinoma


An auxiliary test in the diagnosis of carcinoids, islet cell tumors and neuroblastomas


An auxiliary tool in the assessment of comatose patients

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type


Specimen Required

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic screw-top aliquot tube

Specimen Volume: 0.5 mL

Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 7 days
  Ambient  7 days

Reference Values

≤15 ng/mL

Serum markers are not specific for malignancy, and values may vary by method.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
NSE Neuron Specific Enolase, S 15060-7


Result ID Test Result Name Result LOINC Value
NSE Neuron Specific Enolase, S 15060-7

Reject Due To


Mild reject; Gross reject


Mild OK; Gross OK


Mild reject; Gross reject



Day(s) and Time(s) Performed

Monday through Saturday; 2:30 p.m.

Method Name

Homogeneous Time-Resolved Fluorescence