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Test Code SNTX N-terminal Telopeptide (NTx), Serum

Specimen Required

Patient Preparation: A morning collection from fasting patients is preferred due to diurnal variation of markers and food effects.


Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic screw-top aliquot tube

Specimen Volume: 0.5 mL

Collection Instructions: A morning collection from fasting patients is preferred. If not possible, collect the baseline and subsequent specimens under the same circumstances (eg, at same time of day).

Secondary ID


Useful For

Monitoring effectiveness of antiresorptive therapy in patients treated for osteoporosis or other metabolic bone disorders


As an adjunct in the diagnosis of medical conditions associated with increased bone turnover

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Reporting Name

NTX-Telopeptide, S

Specimen Type


Specimen Minimum Volume

0.1 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Frozen (preferred) 28 days
  Refrigerated  24 hours

Reject Due To


Mild OK; Gross reject


Mild OK; Gross reject


Mild Ok; Gross reject


Reference Values

All units are reported in nmol Bone Collagen Equivalents (BCE)

Adult (≥18 years of age)



5.4-24.2 nmol BCE



Premenopausal: 6.2-19.0 nmol BCE

The target value for postmenopausal adult females undergoing treatment for osteoporosis is the same as the premenopausal reference interval.

Day(s) and Time(s) Performed

Tuesday, Thursday; 10 a.m.

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
SNTX NTX-Telopeptide, S 21215-9


Result ID Test Result Name Result LOINC Value
65558 NTX-Telopeptide, S 21215-9