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Test Code CRYOG Cryoglobulin

Additional Information

Cryoglobulins are abnormal proteins, usually immunoglobulins and other proteins that precipitate at temperatures less than 37° C and redissolve when warmed to above 37° C.  This condition is most commonly found in immunoproliferative, proliferative, and autoimmune disorders.  The conditions associated with cryoglobuminemia include the following:  myeloma, macroglobulinemia, CLL, lupus erythematosus, rheumatoid arthritis, and Sjögren’s Syndrome.

Reflex Tests

Immunofixation Electrophoresis

Collection Container

Call Lab

Specimen Required


Special Handling Instructions

It is preferred that the patient be fasting.

Hospital Collection:  Obtain a warming block from centralized phlebotomy (pager 44701), MOB lab or Wesson Women’s Lab and prewarm two 5mL red top tubes (non-gel barrier). Follow the written protocol attached to the warming block.

Off Site Collection:  Prewarm two 5mL red top tubes (non-gel barrier) in a 37° C until clotted (approximately 2 hours). Centrifuge quickly and separate serum into plastic transport tubes.  Send serum to Flow Cytometry department (pager 44701) at room temperature by courier.

Specimen Volume

10 mL

Minimum Specimen Volume

4 mL

Transport Temperature

Room Temperature.

Specimen Stability

Transport specimen to the Flow Cytometry at BMC Laboratory as soon as possible.

Reasons for Rejection

Mishandling of specimen during collection and processing, such as letting it cool down to below 37° C as a control. Blood collected in a gel barrier tube. Frozen, grossly hemolyzed, and grossly lipemic specimen.


An aliquot of serum is stored at 4° C and observed for formation of a white precipitate or gel.  Serum is then warmed to confirm the reversibility of the precipitate formation.  An additional aliquot is stored at 37° C as a control.

Days and Times Performed

Monday - Friday, 7:30 am - 3:00 pm; Not available on weekends or holidays

Turnaround Time

8 days, up to an additional 7 days for cryoprotein identification.  The cryoprotein identification will be performed at an additional charge to the patient (see Immunofixation Electrophoresis).

Reference Ranges

None detected

CPT Code




EMR Interface Order Code