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Test Code NMHIN N-Methylhistamine, Urine

Reporting Name

N-Methylhistamine, U

Useful For

Screening for and monitoring of mastocytosis and disorders of systemic mast-cell activation, such as anaphylaxis and other forms of severe systemic allergic reactions

 

Monitoring therapeutic progress in conditions that are associated with secondary, localized, low-grade persistent, mast-cell proliferation and activation such as interstitial cystitis

Profile Information

Test ID Reporting Name Available Separately Always Performed
NMH N-Methylhistamine, U No Yes
NCTU Creatinine Concentration No Yes

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Urine


Advisory Information


Individuals who are taking monoamine oxidase inhibitors (MAOIs) or aminoguanidine would have increased N-methylhistamine (NMH) results, which would be uninterpretable.



Specimen Required


Supplies: Aliquot Tube, 5 mL (T465)

Container/Tube: Plastic, 5-mL tube (T465)

Specimen Volume: 5 mL

Collection Instructions:

1. Collect urine for 24 hours.

2. No preservative.

Additional Information:

1. 24-Hour collection is preferred, but a random specimen is also acceptable.

2. See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens in Special Instructions for multiple collections.


Specimen Minimum Volume

3 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 8 days
  Frozen  14 days
  Ambient  24 hours

Reference Values

0-5 years: 120-510 mcg/g creatinine

6-16 years: 70-330 mcg/g creatinine

>16 years: 30-200 mcg/g creatinine

Day(s) and Time(s) Performed

Tuesday, Thursday; 10 a.m.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

82542

LOINC Code Information

Test ID Test Order Name Order LOINC Value
NMHIN N-Methylhistamine, U 44340-8

 

Result ID Test Result Name Result LOINC Value
NCTU_ Creatinine Conc 20624-3
21589 N-Methylhistamine, U 44340-8
TM73 Collection Duration 13362-9
VL63 Urine Volume 3167-4

Reject Due To

Hemolysis

NA

Lipemia

NA

Icterus

NA

Other

NA

Method Name

NMH: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

NCTU: Enzymatic Colorimetric Assay

Urine Preservative Collection Options

Note: The addition of preservative or application of temperature controls must occur within 4 hours of completion of the collection.

Ambient

Yes

Refrigerate

Preferred

Frozen

Yes

50% Acetic Acid

Yes

Boric Acid

Yes

Diazolidinyl Urea

No

6M Hydrochloric Acid

Yes

6M Nitric Acid

Yes

Sodium Carbonate

Yes

Thymol

No

Toluene

No