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Test Code UHIAAQ 5-Hydroxyindoleacetic Acid (5-HIAA), 24 Hour, Urine

Additional Codes

EMR Interface Order Code: 06750

Reporting Name

5-Hydroxyindoleacetic Acid, U

Useful For

Biochemical diagnosis and monitoring of intestinal carcinoid syndrome

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Urine


Necessary Information


24-hour volume is required.

Specimen Required


Patient Preparation:

1. Some medications could interfere with test results. The ordering provider should decide if any medications should be stopped and when they should be restarted. If clinically feasible, discontinue the following medications at least 48 hours prior to, as well as during, specimen collection:

-Acetaminophen (Tylenol or generic versions)

-Aspirin

-Antihistamines

-Cough syrups

-Cold and flu medications

2. For 48 hours prior to, as well as during, the urine collection, the patient should:

Limit the following to 1 serving per day:

-Fruits

-Vegetables

-Nuts

-Caffeinated beverages or foods

 

Supplies: Urine Tubes, 10 mL (T068)

Container/Tube: Plastic, 10-mL urine tube

Specimen Volume: 5 mL

Collection Instructions:

1. Collect a 24-hour urine specimen.

2. Add 25 mL of 50% acetic acid as preservative at start of collection. Use 15 mL of 50% acetic acid for children <5 years old.

Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens in Special Instructions for multiple collections.


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 56 days
  Frozen  365 days

Reference Values

5HIAA, mg/24 hour

99th Percentile Cutoff

Age

Female

Male

≤23 months

≤2.7

≤2.3

24-35 months

≤3.0

≤2.6

3 years

≤3.2

≤2.9

4 years

≤3.4

≤3.2

5 years

≤3.6

≤3.6

6 years

≤3.8

≤3.9

7 years

≤4.0

≤4.2

8 years

≤4.2

≤4.5

9 years

≤4.5

≤4.8

10 years

≤4.7

≤5.1

11 years

≤4.9

≤5.3

12 years

≤5.2

≤5.6

13 years

≤5.4

≤5.8

14 years

≤5.6

≤6.1

15 years

≤5.7

≤6.3

16 years

≤5.9

≤6.4

17 years

≤6.0

≤6.6

18 years

≤6.0

≤6.7

19 years

≤6.1

≤6.8

20 years

≤6.1

≤6.9

21 years

≤6.2

≤6.9

22 years

≤6.2

≤7.0

23 years

≤6.2

≤7.0

24 years

≤6.3

≤7.1

25 years

≤6.3

≤7.2

26 years

≤6.3

≤7.2

27 years

≤6.4

≤7.3

28 years

≤6.4

≤7.4

29 years

≤6.5

≤7.5

30 years

≤6.6

≤7.5

31 years

≤6.6

≤7.6

32 years

≤6.7

≤7.7

33 years

≤6.8

≤7.7

34 years

≤6.8

≤7.8

35 years

≤6.9

≤7.9

36 years

≤6.9

≤7.9

37 years

≤7.0

≤8.0

38 years

≤7.0

≤8.1

39 years

≤7.0

≤8.2

40 years

≤7.1

≤8.2

41 years

≤7.1

≤8.3

42 years

≤7.2

≤8.4

43 years

≤7.3

≤8.5

44 years

≤7.4

≤8.6

45 years

≤7.4

≤8.7

46 years

≤7.5

≤8.8

47 years

≤7.6

≤8.9

48 years

≤7.6

≤9.0

49 years

≤7.7

≤9.1

50 years

≤7.7

≤9.2

51 years

≤7.8

≤9.3

52 years

≤7.8

≤9.4

53 years

≤7.9

≤9.5

54 years

≤8.0

≤9.6

55 years

≤8.1

≤9.7

56 years

≤8.1

≤9.7

57 years

≤8.2

≤9.8

58 years

≤8.3

≤9.8

59 years

≤8.3

≤9.8

60 years

≤8.3

≤9.9

61 years

≤8.3

≤9.9

62 years

≤8.4

≤9.9

63 years

≤8.4

≤10.0

64 years

≤8.4

≤10.0

65 years

≤8.4

≤10.0

66 years

≤8.5

≤10.1

67 years

≤8.5

≤10.1

68 years

≤8.5

≤10.1

69 years

≤8.5

≤10.2

70 years

≤8.5

≤10.2

71 years

≤8.6

≤10.2

72 years

≤8.6

≤10.2

73 years

≤8.5

≤10.1

74 years

≤8.5

≤10.1

75 years

≤8.6

≤10.1

76 years

≤8.6

≤10.0

77 years

≤8.6

≤10.0

78 years

≤8.6

≤10.0

79 years

≤8.6

≤10.0

80 years

≤8.7

≤9.9

81 years

≤8.7

≤9.9

82 years

≤8.7

≤9.9

83 years

≤8.7

≤9.9

84 years

≤8.7

≤9.9

85 years

≤8.6

≤9.8

86 years

≤8.5

≤9.8

87 years

≤8.4

≤9.7

88 years

≤8.3

≤9.7

89 years

≤8.1

≤9.5

90 years

≤7.9

≤9.4

91 years

≤7.6

≤9.2

92 years

≤7.4

≤9.0

93 years

≤7.1

≤8.8

94 years

≤7.0

≤8.7

= 95 years

≤6.9

≤8.6

 

For SI unit Reference Values, see https://www.mayocliniclabs.com/order-tests/si-unit-conversion.html

Day(s) and Time(s) Performed

Monday through Thursday; 11 a.m.

Friday; 2 p.m.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

83497

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HIAA 5-Hydroxyindoleacetic Acid, U 1695-6

 

Result ID Test Result Name Result LOINC Value
9248 5-Hydroxyindoleacetic Acid, U 1695-6
TM35 Collection Duration 13362-9
VL33 Urine Volume 3167-4

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Urine Preservative Collection Options

Note: The addition of preservative or application of temperature controls must occur within 4 hours of completion of the collection.

Ambient

No

Refrigerate

Yes

Frozen

Yes

50% Acetic Acid

Preferred

Boric Acid

Yes

Diazolidinyl Urea

No

6M Hydrochloric Acid

Yes

6M Nitric Acid

Yes

Sodium Carbonate

Yes

Thymol

Yes

Toluene

Yes

Reject Due To

Hemolysis

NA

Lipemia

NA

Icterus

NA

Other

NA